La Roche-Posay Mela B3 Double Dose Serum: a potent day-and-night depigmenting treatment featuring Melasyl and Niacinamide. This formula marks the brand’s first integration of Melasyl™’s targeted depigmentation with Proxylane™’s firming action, delivering a two-pronged approach that tackles stubborn dark spots while restoring facial density and volume. In clinical tests, the serum reduced the intensity of tenacious spots by about 30% and immediately increased firmness by around 20% after a single use. Its light, fluid texture absorbs quickly and leaves no greasy residue, making it easy to add to both morning and evening routines.
Main benefits
- Addresses sun-related and age spots, including the most persistent ones, thanks to the multi-patented Melasyl™ technology.
- Supports the skin’s structural matrix with Proxylane™, enhancing firmness and restoring volume and smoothness.
- Evens skin tone and soothes the complexion with niacinamide, a leading active in dermocosmetics.
- Delivers proven dual action for pigmentation and firmness, usable both day and night.
- Provides lasting results, with reduced staining that remains weeks after completing the course.
Key ingredients
- Melasyl™ (2-Mercaptonicotinoyl Glycine): a multi-patented depigmenting agent that intercepts excess melanin before it marks the skin; efficacy tested against ten market reference molecules.
- Proxylane™ (Hydroxypropyl Tetrahydropyrantriol): the brand’s strongest firming component, reinforcing the skin’s support structure and restoring density and volume.
- Niacinamide: evens tone, calms the skin, and helps mitigate pigmentation-related inflammation.
- LHA (Capryloyl Salicylic Acid): a salicylic derivative that promotes surface renewal and refines texture.
- Brown algae extract (Cystoseira Tamariscifolia Extract): supports the anti-spot action while helping maintain an even complexion.
- Carnosine and adenosine: help preserve skin quality and soften visible aging signs.
- Vitamin E (Tocopherol): an antioxidant protecting skin from daily oxidative stress.
Additional information
Suitable for the face, neck, and décolletage; also tested on hands. Avoid contact with eyes. For optimal protection, finish your morning routine with a broad-spectrum SPF sunscreen. Clinical data include a study with 42 participants tracking the evolution of persistent stain contrast after 12 weeks of twice-daily use, and firmness measurements after a single application in 40 participants. In vivo tests compared activity against multiple agents including ascorbic acid, resveratrol, kojic acid, phenylethyl resorcinol, arbutin, 4-butylresorcinol, niacinamide, ascorbyl glucoside, tranexamic acid, and glutathione.